Pro-Palestinian protesters set off smoke bombs outside a vacation home of American Israel Public Affairs Committee President Michael Tuchin on Thanksgiving Day — while holding a banner reading: “F–k ur holiday! Baby killer.”

Video posted online showed a group of about a dozen protesters hurling smoke bombs as an unidentified man approached the group outside the house in Los Angeles.

A girl could be heard begging her father to “stay away” and “not get physical” as the group chanted, “Hey, ho, the occupation has got to go” and “F— your holiday,” a Thanksgiving message also on the “baby killer” banner.

Other footage shows the group had dripped paint along Tuchin’s driveway and left bunches of cloth covered in fake blood to symbolize dead babies.

The People’s City Council-Los Angeles, which describes itself as an anticapitalist and anti-imperialist group, took credit for the protest, calling it a “holiday wake-up call.”

“AIPAC spends tens of millions to control pro-genocide Congress members,” it wrote on X. “F–k your holiday, baby killer.”

Watchdog group StopAntisemitism shared the videos on X, calling the rally “horrifying.

“What’s next? The burning of synagogues and schools like in 1939 Germany?” it asked.

The Los Angeles Police Department told The Post officers responded to the scene at around 10:45 a.m. and took crime reports for investigation into potential vandalism/hate crime and assault with a deadly weapon charges.

Both investigations are ongoing.

AIPAC, a nonpartisan, pro-Israel political action committee that lobbies for Israeli interests in Washington, has faced criticism since Israel’s military response to the Oct. 7 slaughter of more than 1,200 people by Hamas terrorists.

Progressive Rep. Alexandria Ocasio-Cortez earlier this month called it a “racist and bigoted organization.”

“They are no friend to American democracy,” Ocasio-Cortez wrote on X. “They are one of the more racist and bigoted PACs in Congress as well, who disproportionately target members of color.

“They are an extremist organization that destabilizes US democracy.”

The group responded by saying AOC was spreading “more of the same tired lies and spin.

“@AOC and the Squad summed up: People who disagree with us are racist,” AIPAC posted on X, noting it “stands with pro-Israel Democrats and Republicans of all races, genders, and backgrounds who support the US-Israel alliance. And we oppose those who don’t, like you.”

The Post has reached out to local law enforcement for more information on the protest, as well as to AIPAC for comment.