MANAMA, Bahrain—U.S. and British warships shot down one of the largest barrages of missiles and drones fired by Yemen’s Houthi rebels into the crucial Red Sea shipping lane, while Secretary of State Antony Blinken continued his efforts to prevent the conflict in Gaza from escalating into a regional war.

The U.S. is considering conducting strikes against land-based Houthi targets in Yemen in response to the attacks in the Red Sea, officials said. The overnight barrage would likely elicit a U.S. response, a defense official said Wednesday.

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